Cannabis is nothing less than a magical herb. You can use it for various purposes, from recreational purposes to medical purposes. Whether you want to consume it to just chill out after a long day or to manage a condition, it won’t disappoint you. However, you use cannabis for medical purposes, you need to get a medical marijuana recommendation from a licensed doctor. But, have you ever noticed that sometimes your friends experience completely different reactions to the same herb? Well, there are certain reasons why this happens. And today we will learn about all these reasons in this article.

You might have a friend who gets too high after just a few puffs of a joint. Or someone who won’t feel anything while you are already feeling drowsy. There are various factors that play a big role when it comes to cannabis experience. For example, women and men may experience the effects of THC (tetrahydrocannabinol) in different ways. THC is one of the main compounds present in cannabis. It is responsible for the psychoactive “high” we experience after consuming cannabis.

Every human body consists of cannabinoid receptors. And THC produces the psychoactive effects by interacting with these receptors. That is why if you consume THC, you will experience at least some effects of it. However, if you are not getting high, there can be various reasons for it. If you are facing issues in getting high, these could be the reasons –

You are not inhaling properly

One of the most common reasons why many of us do not experience the effects of cannabis is because we’re not inhaling properly. The most popular and traditional way of consuming cannabis is to smoke it. And sometimes people just don’t inhale the smoke properly. This is especially true for beginners. Inhaling properly is important for the active compounds of cannabis to successfully enter the lungs. They are then absorbed into the bloodstream from the lungs. So, not inhaling properly can directly impact your experience of consuming cannabis. Here’s how you can inhale cannabis in the right way.

  • Slowly start inhaling through the mouth
  • Inhale deeply so that the smoke reaches your lungs. Take deep breaths using your diaphragm.
  • Then exhale slowly keeping it in control.

If you are smoking cannabis for the first time or are a beginner, the cough may follow your first inhalation. But with practice, you will learn how to control your breath better.

Method of consumption

Another reason why you are not getting high could be your method of consumption. I have seen some people who simply just don’t get high from cannabis edibles. Eating edibles is different from smoking cannabis. When you eat cannabis edibles, THC has to go through the digestive tract and get metabolized before you feel the effects. The entire process metabolizes THC into a more potent psychoactive molecule, 11-hydroxy-THC. This is why edibles offer a stronger high that also lasts for a longer period.

But, this is not the case for some people. The genetic variation of these people may make it hard for their bodies to break down THC. and Some of them may not convert THC into a more active form. That’s why these people will not experience the psychoactive effects of edibles. Smoking and vaporization can be the better methods of consumption for them.

Now let’s find out the reasons why cannabis affects some people differently.


Your genes play a major role in determining your experience with cannabis. Whether it is THC or CBD, the effects of cannabinoids of cannabis depend upon your genes. Recent research shows that around 20 percent of the adult population of the United States has certain genetic mutations. This is leading to increased levels of the endocannabinoids present in the body naturally. People who are a part of this 20 percent population are more prone to the anxiety produced by THC. But, in general, these people will also not show any reactions to the effects of THC and CBD. This happens because the bodies of these people are already producing high levels of cannabinoids.

People who have lower levels of endocannabinoids (below the average) tend to experience more psychoactive effects of THC. But, they will also react to it in a better way. This has both perks and disadvantages for you if you are one of them. For example, you won’t have to buy too much cannabis to experience high. But, at the same time, you will have to pay more attention to the amount of cannabis you are consuming.

Unique biochemistry

Billions of biochemical processing take place around the body at any given moment. Whether it’s electrical impulses running through the nerve fibers or the proteins being formed by the cells, this includes everything. Everyone has a unique biochemistry. This is why cannabinoids of cannabis interact in a different way.

You might have seen some people who are more sensitive to cannabis than others. Or someone bouncing off the walls after having just one cup of coffee. This happens because of the endocannabinoid system of our bodies. There are certain factors that can influence the work of the endocannabinoid system. These include – genetics, stress, diet, and lifestyle, habits, other medications and supplements, and more.

Endocannabinoids come from fatty acids. So, if your diet is low in healthy fats, your ECS may not stay strong enough. This will lead you to become more prone to anxiety and psychoactive effects produced by cannabis.

Your gender

People are focusing more and more on gender equality. But the cannabinoids present in cannabis do not really care much about that. The effects of cannabis are different for men and women. So, the chances are that you will experience the effects of cannabis a bit differently from your counter-sex.

Men are more likely to experience the munchies after smoking cannabis. But women are more sensitive to the overall effects of cannabis when it comes to their health. Also, they need to consume fewer amounts of cannabis than men to experience the pain-relieving effects of cannabis.

Is it that time of the month, ladies? Well, that also influences your experience of cannabis. THC works closely with estrogen. So, the effects of THC become more powerful when estrogen levels have reached their peak and are on the decline.

Your tolerance level

This is probably the most obvious one out of all the reasons. If you consume cannabis a lot, on a regular basis, you will soon start responding to it in a very different way than the others who do not. The more you consume, the greater your tolerance for cannabis. This happens because your body starts becoming used to it, and you become less sensitive to it. Whether you are using medical cannabis after getting your medical marijuana recommendation or recreational cannabis, your tolerance will increase with time.

So, a person who is consuming cannabis for the first time will react to it in a very different way to the same strain and dose. The body of a beginner is not used to cannabinoids of cannabis and hence reacts in a different way.